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What is emtricitabine?

Emtricitabine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults, children, and infants. While emtricitabine is approved for all ages, it has not been studied fully in adults over age 65. Emtricitabine is always used in combination with other HIV medicines.

Emtricitabine belongs to a group of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including emtricitabine, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.

Because emtricitabine is also effective against hepatitis B virus infection (HBV), it may be included in an HIV treatment regimen to treat HBV infection in people with HIV. In addition to emtricitabine, the HIV treatment regimen should include another drug that is effective against both HBV and HIV. Emtricitabine should not be used to treat HBV infection in people with HIV who are not receiving antiretroviral therapy (ART). For information on the HBV-related use of emtricitabine, please refer to the HBV section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents.

What side effects can emtricitabine cause?

Emtricitabine may cause side effects. Most side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.

Some side effects of emtricitabine can be serious. Serious side effects of emtricitabine include a buildup of lactic acid in the blood (lactic acidosis) and serious liver problems. If you have HBV, you may have sudden worsening (a flare up) of your HBV infection if you stop taking emtricitabine. (See section above: What are the most important things to know about emtricitabine?)

Other possible side effects of emtricitabine include:

• Changes in your immune system(called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
• Skin discoloration.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of emtricitabine. To learn more about possible side effects of emtricitabine, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online